Symposium Chair(s):
Jiacan Su, Yuxiao Lai, Long Bai
Title of Symposium:
Intelligent Organoid Biomanufacturing
Symposium Description:
Organoids are transitioning from small-scale lab systems to manufacturable, standardized, and scalable micro-physiological platforms. This symposium defines an end-to-end framework for Intelligent Organoid Biomanufacturing: beginning with data-driven digital design that fuses multi-omics and imaging, leveraging generative/inverse design and reinforcement learning for process modeling and adaptive control; covering biofabrication operations including 3D/4D bioprinting, microfluidic assembly, control of self-organization, and advanced bioinks/materials with organ-on-chip integration; emphasizing scale-up via robotics, closed-loop culture, perfusion bioreactors, and continuous production; and strengthening quality through in-line sensing and metrology (label-free imaging, single-cell and functional readouts) with clear release criteria (identity/purity/function). We will also address data, standards, and compliance-GMP/GxP, traceability, FAIR data and provenance, as well as ethics and safety. Oriented by manufacturability, reproducibility, and cost, the session will feature case studies spanning pharma, med-tech, and biofoundries, converge on benchmarks and reference materials, and accelerate the evolution of organoids from artisanal science to engineered products ready for industrial translation.
